|
KMID : 1134819970260050908
|
|
Journal of the Korean Society of Food Science and Nutrition
1997 Volume.26 No. 5 p.908 ~ p.913
|
|
|
Phospholipase A₂ Activity and Lipid Peroxidation in Liver Microsome of Streptozotocin Induced Diabetic Rats
|
|
Rhee Soon-Jae
Choi Jeong-Hwa
|
|
|
Abstract
|
|
|
|
The purpose of this study was to investigate phospholipase A₂ activity and lipid peroxidation in streptozotocin induced diabetic rats. Sprague-Dawley male rats weighting 300±10gm were randomly assigned to normal and STZ-induced diabetic group. Diabetes was induced by intravenous injection of 55㎎/㎏ of STZ in sodium citrate buffer(pH 4.3). Animals were sacrificed at the 6th day of diabetic states. Body weight gains were lower in DM group. Phosphatidylcholine hydrolysis in liver was not significantly different between two groups, whereas phosphatidylethanolamine hydrolysis in liver was increased by 69% in DM group comparing with that of normal group. Liver microsomal phospholipase A₂ activity and level of TBARS was increased by 91%, 109% in DM group compared with that of normal group, respectively. The present results indicate that phospholipase A₂ activity is specific to PE hydrolysis, leading to lipid peroxidation process in STZ induced diabetic rats.
|
|
|
KEYWORD
|
|
|
diabetes, phospholipase $A_{2}$ , lipid peroxidation
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|